Interesting article on depression.
The researchers also found that three patient characteristics made treatment failure more likely: suicidal thoughts, unemployment and lack of adherence to medication.
Suicidal thoughts denote more severe depression, Sherbourne explained, and lack of work could be a sign of poor functioning in daily life. As for non-compliance with drugs, she noted, side effects are often to blame when patients stop taking their medication before they should.
All of these factors could make a person's depression particularly hard to treat, according to Sherbourne.